Kuhlmann and colleagues obtained data and blood samples from 106 people, each of whom participated in one of four such studies. Nonetheless, any remaining healthy participants also were given antibiotics to clear the bacteria before going home. The disease comes on quickly, so anyone who was still healthy at the end of five days was unlikely to get sick later. Those who developed moderate to severe diarrhea were treated with antibiotics. Then, they observed the volunteers for five days. coli strain originally isolated from a person in Bangladesh with severe, cholera-like diarrhea. In controlled human infection clinical trials, researchers at Johns Hopkins University gave healthy volunteers a dose of an E. Fleckenstein, instructor in medicine Matthew Kuhlmann, MD, postdoctoral researcher Pardeep Kumar, PhD, and colleagues investigated whether blood type influences disease severity by looking at what happened to people of different blood types who drank a cup of water laced with E. coli in Bangladesh seemed to get sicker if they had blood type A, but the reason for this was never tested. Years ago, doctors noted that children naturally infected with enterotoxigenic E. That outbreak involves a different kind of E. coli are not the cause of the current romaine lettuce-related outbreak. Others experience unpleasant symptoms but recover easily, while some don’t get sick at all.Įnterotoxigenic E. Some people infected with the bacterium develop severe, cholera-like, watery diarrhea that can be lethal. It primarily infects people living in or visiting developing countries. coli are responsible for millions of cases of diarrhea and hundreds of thousands of deaths every year, mainly of young children. The work was conducted in collaboration with investigators at Johns Hopkins University, the National Institutes of Health (NIH), and the Naval Medical Research Center.Įnterotoxigenic E. The study is published May 17 in The Journal of Clinical Investigation. “A vaccine targeting this protein would potentially protect the individuals at highest risk for severe disease.” “We think this protein is responsible for this blood-group difference in disease severity,” said senior author James Fleckenstein, MD, an associate professor of medicine at Washington University. A vaccine targeting that protein could potentially protect people with type A blood against the deadliest effects of enterotoxigenic E. The bacteria release a protein that latches onto intestinal cells in people with blood type A, but not blood type O or B, according to a study led by researchers at Washington University School of Medicine in St. coli most associated with “travelers’ diarrhea” and children in underdeveloped areas of the world causes more severe disease in people with blood type A. The findings could potentially lead to a vaccine to help protect people living in or visiting developing countries.Ī new study shows that a kind of E. coli (shown in a computer-generated image above) than people with blood group O or B. People with blood group A are more likely to develop severe diarrhea when infected with a kind of E. Alissa Eckert and Jennifer Oosthuizen/CDC.Researchers ID protein responsible for blood-group differenceīy Tamara Bhandari News Release Blood type affects severity of diarrhea caused by E.
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